Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia

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Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.

IMPORTANCE Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable. OBJECTIVE To develop a measure of grammatical comprehension and examine this comparatively in PPA variants and behavioural-variant frontotemporal degen...

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Core auditory processing deficits in primary progressive aphasia

The extent to which non-linguistic auditory processing deficits may contribute to the phenomenology of primary progressive aphasia is not established. Using non-linguistic stimuli devoid of meaning we assessed three key domains of auditory processing (pitch, timing and timbre) in a consecutive series of 18 patients with primary progressive aphasia (eight with semantic variant, six with non-flue...

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The neural basis of syntactic deficits in primary progressive aphasia.

Patients with primary progressive aphasia (PPA) vary considerably in terms of which brain regions are impacted, as well as in the extent to which syntactic processing is impaired. Here we review the literature on the neural basis of syntactic deficits in PPA. Structural and functional imaging studies have most consistently associated syntactic deficits with damage to left inferior frontal corte...

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Grammatical category-specific deficits in bilingual aphasia.

We report the naming performance of an early and highly proficient Spanish-Catalan bilingual (JPG) suffering from Primary Progressive Aphasia (PPA). JPG's performance revealed a grammatical category-specific deficit, with worse performance in naming verbs than nouns. This dissociation was present in oral and written naming and in his two languages, and it seems to stem from damage to, at least,...

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Right Hemisphere Involvement in Non-Fluent Primary Progressive Aphasia

We described a 56-years-old man with a diagnosis of "non-fluent primary progressive aphasia" (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient. From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2013

ISSN: 0022-3050

DOI: 10.1136/jnnp-2013-305749